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BD²: Breakthrough Discoveries for thriving with Bipolar Disorder funds science in search of ways to help every person with bipolar disorder thrive. We seek multidisciplinary teams to collaborate and explore the fundamental mechanisms, heterogeneity, progression, and underlying biology of the disorder to dramatically improve systems of care and accelerate research.

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Since launch, BD² has invested $78M+ in research commitments.

Funding Opportunities:
Requests for Applications (RFAs)

Showing 8 of 10 results.
Title Description Amount Year/Status RFA Links
Integrated Network

BD² Integrated Network Mobile Application Partner

BD² seeks applications from qualified organizations or teams to develop and manage a comprehensive mobile application system for data collection, monitoring, and analysis for the Integrated Network. The BD² Integrated Network is part of a multidisciplinary initiative to increase the scientific understanding and, ultimately, to improve care and interventions for bipolar disorder.

Amount: up to $1,350,000
over 5 years
Year/Status: 2024Open Now Download RFA Submit Application
Integrated Network

BD² Integrated Network Site, Wave 2

The BD² Integrated Network, in partnership with people living with bipolar disorder and their care teams, engages a network of collaborating investigators and clinicians to build an unprecedented data ecosystem for bipolar disorder, implement and inform data-driven improvements in care, and generate novel insights for interventional approaches.

Amount: up to $2,300,000
over 5 years
Year/Status: 2024Inactive Download RFA Download FAQ
Discovery Research

Discovery Research, Cycle 3

The Discovery Research program aims to delineate the etiology and biological mechanisms of bipolar disorder, allowing the development of effective interventions. We fund multidisciplinary teams of scientists and clinicians who generate new hypotheses and drive innovation in the exploration of causal mechanisms of bipolar disorder with an eye toward novel treatments.

Amount: up to $4,500,000
over 3 years
Year/Status: 2024Inactive Download RFA Watch the Webinar
Discovery Research

Discovery Research, Cycle 2

The Discovery Research program supports an innovative and collaborative group of researchers working together to improve our understanding of the biological mechanisms that underlie bipolar disorder. We seek multidisciplinary teams of scientists to develop targeted and groundbreaking research applications that will examine the genetic, molecular, cellular, circuit, and/or behavioral mechanisms of bipolar disorder.

Amount: up to $4,500,000
over 3 years
Year/Status: 2023Inactive Download RFA FAQ
Integrated Network

BD² Integrated Network Clinical Coordinating Center (CCC)

As part of the BD² Integrated Network, the CCC provides expert guidance and logistical support including key diagnostics and clinical assessments, Institutional Review Board activities, a rigorous study monitoring plan, and coordination of clinical care activities.

Amount: up to $5,400,000
over 5 years
Year/Status: 2022Inactive Download RFA
Integrated Network

BD² Integrated Network Data Coordinating Center & Centralized Repository (DCC)

As part of the BD² Integrated Network, the DCC provides technical and logistical support for iterative cycles of data aggregation, analyses, and implementation.

Amount: up to $5,000,000
over 5 years
Year/Status: 2022Inactive Download RFA
Integrated Network

BD² Integrated Network Site

In partnership with people living with bipolar disorder, clinicians, and researchers, the BD² Integrated Network brings together a community committed to dramatically improving systems of care and accelerating research. Integrated Network sites make up a learning health network (LHN) with the goal of rapid integration of data analytics from research to inform clinical care.

Amount: $2,250,000
over 5 years
Year/Status: 2022Inactive Download RFA
Brain Omics Platform

Brain Omics Platform

The Brain Omics Platform analyzes a variety of epigenetic, transcriptomic, proteomic, and other omic characteristics of human brain tissue from people with bipolar disorder. Our partners conduct state-of-the-art research to develop the molecular atlas of neural and non-neural changes in people with bipolar disorder.

Amount: up to $5,000,000
for up to 3 years
Year/Status: 2022Inactive Download RFA